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abemaciclib

Pronunciation: a BEM a SYE klib

Brand: Verzenio

What is the most important information I should know about abemaciclib?

Abemaciclib can cause severe diarrhea, which can lead to dehydration or infection. Call your doctor right away if you have diarrhea. Drink extra fluids and start taking anti-diarrhea medicine such as loperamide (Imodium).

Abemaciclib can cause blood clots, liver problems, or serious and sometimes fatal infections. Call your doctor right away if you have symptoms such as: fever, chills, easy bruising or bleeding, unusual tiredness, loss of appetite, right-sided upper stomach pain, chest pain, shortness of breath, rapid breathing, fast heartbeats, or pain or swelling in your arms or legs.

What is abemaciclib?

Abemaciclib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Abemaciclib is used to treat advanced hormone-related breast cancer. Abemaciclib is used for this condition only if your tumor tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells.

Abemaciclib is used when the cancer has progressed or has spread to other parts of the body after treatment with anti-estrogen medication or other chemotherapy.

When used in women, abemaciclib is given with another medicine called fulvestrant.

Abemaciclib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking abemaciclib?

You should not use abemaciclib if you are allergic to it.

To make sure abemaciclib is safe for you, tell your doctor if you have:

  • a fever, chills, or other signs of infection; or
  • liver or kidney disease.

You may need to have a negative pregnancy test before starting this treatment.

Using abemaciclib during pregnancy could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your treatment ends. Tell your doctor right away if you become pregnant during this time.

It is not known whether abemaciclib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine and for at least 3 weeks after your last dose.

How should I take abemaciclib?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take abemaciclib with or without food.

Take the medicine at the same time each day.

Do not crush, chew, or break the tablet. Swallow it whole.

If you vomit shortly after taking abemaciclib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Drink plenty of liquids while you are taking abemaciclib.

Abemaciclib can cause severe diarrhea, which can be life-threatening if it leads to dehydration or infection.

If you have diarrhea while taking abemaciclib: start taking anti-diarrhea medicine such as loperamide (Imodium) to quickly treat diarrhea. Drink extra fluids and call your doctor.

Abemaciclib can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking abemaciclib?

Grapefruit and grapefruit juice may interact with abemaciclib and lead to unwanted side effects. Avoid the use of grapefruit products while taking abemaciclib.

What are the possible side effects of abemaciclib?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe or ongoing diarrhea;
  • pain or burning when you urinate;
  • liver problems --right-sided upper stomach pain, loss of appetite, easy bruising or bleeding, feeling very tired; or
  • low blood cell counts --fever, chills, flu-like symptoms, cough with mucus, mouth sores, skin sores, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • nausea, vomiting, stomach pain;
  • loss of appetite;
  • feeling tired;
  • headache; or
  • low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect abemaciclib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • ketoconazole.

This list is not complete. Other drugs may interact with abemaciclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about abemaciclib.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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