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aspirin and omeprazole

Pronunciation: AS pir in and oh MEP ra zole

Brand: Yosprala

What is the most important information I should know about aspirin and omeprazole?

You should not use this medicine if you have severe breathing problems, sinus problems, or nasal polyps, if you take medicine that contains rilpivirine, or if you've had an asthma attack or severe allergic reaction to aspirin or an NSAID (nonsteroidal anti-inflammatory drug).

Aspirin and omeprazole can cause serious side effects. Call your doctor if you cough up blood or if you have bloody or tarry stools, unusual bleeding or bruising, decreased urination, joint pain and a rash on your face and arms, or sudden pain in your wrist, thigh, hip, or back.

What is aspirin and omeprazole?

Aspirin is a salicylate (sa-LIS-il-ate) that reduces substances in the body that cause pain, fever, and inflammation. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Aspirin and omeprazole is a combination medicine used to help lower the risk of heart problems, strokes, or death in people who have had certain conditions related to blood clots, including angina (chest pain), a past heart attack, or a "mini stroke."

Aspirin and omeprazole is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.

Omeprazole helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.

Aspirin and omeprazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking aspirin and omeprazole?

You should not use this medicine if you are allergic to aspirin or omeprazole, or if:

  • you have severe breathing problems, asthma, sinus problems, or nasal polyps (growths inside your nose);
  • you take medicine that contains rilpivirine (Edurant, Complera, Juluca, Odefsey); or
  • you've had an asthma attack or severe allergic reaction after taking aspirin or an NSAID (nonsteroidal anti-inflammatory drug).

This medicine is not approved for use by anyone younger than 18 years old. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

Aspirin and omeprazole should not be used to treat a sudden onset of heart attack or stroke symptoms (chest pain, sudden numbness or weakness, slurred speech).

Tell your doctor if you have ever had:

  • a bleeding disorder or vitamin K deficiency;
  • low levels of magnesium in your blood;
  • liver or kidney disease;
  • lupus; or
  • if you are of Asian descent.

Taking this medicine may increase your risk of bone fracture in the hip, wrist, or spine. Your risk is highest if you take the medicine long term or at high doses, and if you are age 50 or older.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine may temporarily affect your ability to get pregnant. Talk with your doctor if this concerns you.

You should not breast-feed while using aspirin and omeprazole.

How should I take aspirin and omeprazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the lowest dose that is effective in treating your condition.

Take this medicine with a full glass of water. The usual dose is once daily, 1 hour before a meal.

Swallow the tablet whole and do not crush, chew, or break it.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using aspirin and omeprazole.

Omeprazole may affect a drug-screening urine test and you could have false results. Tell the laboratory staff that you use aspirin and omeprazole.

Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may increase your risk of heart attack or stroke. Follow your doctor's instructions about tapering your dose.

If you use this medicine for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include ringing in your ears, increased thirst, muscle pain or weakness, trouble breathing, or feeling cold.

What should I avoid while taking aspirin and omeprazole?

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to aspirin or omeprazole.

Taking regular aspirin together with omeprazole (Prilosec) will not work the same way as taking combination aspirin and omeprazole (Yosprala). Do not substitute this medicine with over-the-counter products.

Drinking alcohol can increase your risk of stomach bleeding.

What are the possible side effects of aspirin and omeprazole?

Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe nausea, vomiting, stomach pain, or diarrhea that is watery or bloody;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • easy bruising, unusual bleeding (such as a nosebleed), or any bleeding that will not stop;
  • sudden pain or trouble moving your hip, wrist, or back;
  • kidney problems --urinating less than usual, blood in your urine, swelling, skin rash, unusual breath odor;
  • liver problems --stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);
  • lupus-like syndrome --joint pain or swelling, skin rash on your face or arms that worsens in sunlight;
  • symptoms of low vitamin B-12 levels --pale skin, tingling or numbness, muscle weakness, feeling light-headed or short of breath, tiredness, mood changes; or
  • symptoms of low magnesium --dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms in your hands and feet, cough or choking feeling.

Common side effects may include:

  • heartburn, stomach pain, indigestion;
  • nausea, diarrhea; or
  • chest pain (may happen when you eat).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aspirin and omeprazole?

Tell your doctor about all your other medicines, especially:

  • clopidogrel;
  • digoxin;
  • methotrexate;
  • rifampin;
  • St. John's wort;
  • ticagrelor; or
  • a diuretic or "water pill."

This list is not complete. Other drugs may affect aspirin and omeprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about aspirin and omeprazole.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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